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KMID : 1035620190070020078
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Allergy Asthma & Respiratory Disease
2019 Volume.7 No. 2 p.78 ~ p.85
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Seasonal patterns and etiologies of croup in children during the period 2010?2015: A multicenter retrospective study
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Lee Yong-Ju
Kim Hyo-Bin
Kim Bong-Seong
Kim Chang-Keun
Kim Cheol-Hong
Kim Hyung-Young
Kim Sang-Young
Kim Yun-Sun
Park Cho-Rong
Seo Ju-Hee
Sol In-Suk
Sung Myong-Soon
Song Min-Seob
Song Dae-Jin
Ahn Young-Min
Oh Hea-Lin
Yu Jin-Ho
Lee Kyung-Suk
Lee Eun
Lee Ju-Seok
Jang Gwang-Cheon
Jang Yong-Seok
Chung Eun-Hee
Chung Hai-Lee
Choi Sung-Min
Choi Yun-Jung
Han Man-Yong
Yang Hyeon-Jong
Shim Jung-Yeon
Kim Jin-Tack
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Abstract
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Purpose: Croup is known to have epidemics in seasonal and biennial trends, and to be strongly associated with epidemics of parainfluenza virus. However, seasonal and annual epidemics of croup have not been clearly reported in Korea. This study aimed to examine the seasonal/annual patterns and etiologies of childhood croup in Korea during a consecutive 6-year period.
Methods: Pediatric croup data were collected from 23 centers in Korea from 1 January 2010 to 31 December 2015. Electronic medical records, including multiplex reverse transcription polymerase chain reaction (RT-PCR) results, demographics and clinical information were cross-sectionally reviewed and analyzed.
Results: Overall, 2,598 childhood croup patients requiring hospitalization were identified during the study period. Among them, a total of 927 who underwent RT-PCR were included in the analysis. Males (61.5%) predominated, and most (63.0%) of them were younger than 2 years of age (median, 19 months; interquartile range, 11?31 months). Peak hospitalization occurred in 2010 and 2012 in even-numbered years, and parainfluenza virus (PIV, 39.7%) was the most common cause of childhood croup requiring hospitalization, followed by respiratory syncytial virus (14.9%), human rhinovirus (12.5%), Mycoplasma pneumonaie (10.6%), and human coronavirus (7.3%).
Conclusion: It is concluded that croup hospitalization has a biennial pattern in even-numbered years. PIV may be the most common cause of childhood croup; however, croup epidemics could be attributed to other viruses.
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KEYWORD
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Child, Croup, Hospitalization, Retrospective studies, Seasons
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